Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-03-01
2011-03-01
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S350000, C549S505000
Reexamination Certificate
active
07897606
ABSTRACT:
Disclosed are compounds of the formulaand the pharmaceutically acceptable salts thereof. The compounds are useful for the treatment of chemokine-mediated diseases such as COPD.
REFERENCES:
patent: 4170588 (1979-10-01), Hegenberg et al.
patent: 4639523 (1987-01-01), Nohara et al.
patent: 5206252 (1993-04-01), Butera et al.
patent: 5354763 (1994-10-01), Butera et al.
patent: 5397790 (1995-03-01), Butera et al.
patent: 5401753 (1995-03-01), Butera et al.
patent: 5403853 (1995-04-01), Butera et al.
patent: 5466712 (1995-11-01), Butera et al.
patent: 5506252 (1996-04-01), Butera et al.
patent: 5532245 (1996-07-01), Butera et al.
patent: 5840764 (1998-11-01), Quagliato et al.
patent: 6300325 (2001-10-01), Widdowson et al.
patent: 6376555 (2002-04-01), Butera et al.
patent: 6420396 (2002-07-01), Albers et al.
patent: 2001/0018447 (2001-08-01), Widdowson et al.
patent: 2003/0204085 (2003-10-01), Taveras et al.
patent: 2004/0034229 (2004-02-01), Taveras et al.
patent: 2004/0053953 (2004-03-01), Taveras et al.
patent: 2004/0186142 (2004-09-01), Taveras et al.
patent: 2006/0025453 (2006-02-01), Taveras et al.
patent: 2006/0223864 (2006-10-01), Biju et al.
patent: 2007/0004682 (2007-01-01), Biju
patent: 2007/0264230 (2007-11-01), Taveras et al.
patent: 2009/0131445 (2009-05-01), Baures et al.
patent: 33 09 655 (1984-09-01), None
patent: 0 040 696 (1981-12-01), None
patent: 0 067 436 (1982-12-01), None
patent: 0 099 121 (1984-01-01), None
patent: 0 275 997 (1988-07-01), None
patent: 0 376 079 (1990-07-01), None
patent: 0 796 243 (1997-09-01), None
patent: 1 529 531 (2005-05-01), None
patent: 1186096 (1970-04-01), None
patent: 2124622 (1984-02-01), None
patent: 2132190 (1984-07-01), None
patent: WO 94/29277 (1994-12-01), None
patent: WO 95/14005 (1995-05-01), None
patent: WO 96/14300 (1996-05-01), None
patent: WO 96/15103 (1996-05-01), None
patent: WO 98/33763 (1998-08-01), None
patent: WO 00/20378 (2000-04-01), None
patent: WO 00/21927 (2000-04-01), None
patent: WO 00/35855 (2000-06-01), None
patent: WO 00/35864 (2000-06-01), None
patent: WO 00/73260 (2000-12-01), None
patent: WO 01/28987 (2001-04-01), None
patent: WO 01/29000 (2001-04-01), None
patent: WO 01/64208 (2001-09-01), None
patent: WO 01/64691 (2001-09-01), None
patent: WO 01/68569 (2001-09-01), None
patent: WO 01/79209 (2001-10-01), None
patent: WO 01/92202 (2001-12-01), None
patent: WO 02/044378 (2002-06-01), None
patent: WO 02/057230 (2002-07-01), None
patent: WO 02/067919 (2002-09-01), None
patent: WO 02/076926 (2002-10-01), None
patent: WO 02/083624 (2002-10-01), None
patent: WO 03/031440 (2003-04-01), None
patent: WO 03/057676 (2003-07-01), None
patent: WO 03/080053 (2003-10-01), None
patent: WO 2004/011418 (2004-02-01), None
patent: WO 2005/051974 (2005-06-01), None
patent: WO 2006/044402 (2006-04-01), None
patent: WO 2007/002764 (2007-01-01), None
Starchenkov, B., et al., Chemistry of Furazono[3,4-b]Pyrazines 3. Method for the Synthesis of 5,6-Disubstitued Furazano[3,4-b]Pyrazines, Chemistry of Heterocyclic Compounds, vol. 33, No. 10, 1997, 1219-1233.
Fernandez, E., et al., Solid-phase versus solution synthesis of asymmetrically disubstituted furazano[3,4-b]pyrazines, Tetrahedron Letters 43 (2002) 4741-4745.
PCT International Search Report dated Aug. 11, 2006, for corresponding PCT Application No. PCT/US2006/024908.
Chemical Abstract 66:18527 for Maahs, Guenther, et al., “Syntheses and derivatives of squaric acid,”Angewandte Chemie78(20):927-31 (1966).
Chemical Abstract 87:134383 for Augustin, Manfred, et al., “Disubstitution in 2,3-dichloromaleimides”Zeitschrift Fuer Chemie17(6):215-216 (1977).
Chemical Abstract No. 87:151727 for Ehrhardt, Heinz, et at., “Amides and thioamides of squaric acid: syntheses and reactions,”Chemische Berichte110(7):2506-23 (1977).
Chemical Abstract 104:129517 for Gruenefeld, Johann, et al., “Reactions of squaric acid with carbodiimides,”Archiv der Pharmazie318(12):1062-70 (1985).
Chemical Abstract No. 122:160745 for Tillack, Annegret, et al., “Assymmetric catalysis. IV. Hydrosilylation of acetophenone with pyrroline-2,5-dione modified [Rh(COD)C1]2 catalyst,”Journal of Organometallic Chemistry482:85-91 (1994).
Chemical Abstract No. 125:300482 for Chen, Yizhao, et al., “Reaction of dibutyl oxosquarate with aromatic primary amines,”Sichuan Daxue Xuebao, Ziran Kexueban33(2): 182-186 (1996).
Chemical Abstract No. 130:222994 for Chen, Yi-Zhao, et al., “Synthesis of asymmetric aryl-substituted amides of squaric acid and asymmetric isosquarylium amides,”Hechen Huaxue6(4):383-392 (1998).
Butera, John A., et al., “Design and SAR of Novel Potassium Channel Openers Targeted for Urge Urinary Incontinence. 1.N-Cyanoguanidine Bioisosteres Possessing in Vivo Bladder Selectivity,”J. Med. Chem.43:1187-1202 (2000).
Davis, Peter D., et al., “Inhibitors of protein kinase C 1. 2,3-Bisarylmaleimides,”J. Med. Chem.35:177-184 (1992).
Hanaineh-Abdelnour, Leila, et al., “Some synthetic applications of 2,3-Dichloro-N-phenylmaleimide: A Novel Synthesis of 2-Phenylpyrrolo[3,4-b]quinoxaline-1,3-diones. I,”Tetrahedron55:11859-11870 (1999).
Hoffman, Jacob M., et al., “Conformational Requirements of Histamine H2-Receptor Inhibitors: Structure-Activity Study of Phenylene Analogues Related to Cimetidine and Tiotidine,”Journal of Medicinal Chemistry26(2):140-44 (1983).
Karady, Sandor, et al., “1,2,5-Thiadiazole-1-Oxides.I.Synthesis and Reactions of Alkoxy and Alkythio Analogs,”Heterocycles16(9):1561-4 (1981).
Martinez, Ana, et al., “Synthesis of Nonsymmetrically 3,4-Disubstituted 1,2,5-Thiadiazole Dioxides,”Journal of Heterocyclic Chemistry35(2):297-300 (1998).
Neuse, Eberhard W., et al., “Poly(squaryl amides)”Polymer15:339-45 (1974).
Patent Abstracts of Japan, vol. 018, No. 361 (c-1222), Jul. 7, 1994 and JP 06 092915A, Apr. 5, 1994 abstract.
Schostarez, Heinrich J., et al., “Cyanoguanidine Bioisosteres in Potassium Channel Openers: evaluation of 3,4-Disubstituted-1,2,5-Thiadiazole-1-Oxides,”Bioorganic&Medicinal Chemistry Letters6(18):2187-92 (1996).
Wen, Richard Y., et al., “The Chemistry of 1,2,5-Thiadiazoles. II. 3,4-Disubstituted Derivatives of 1,2,5-Thiadiazole 1,1-Dioxide,”J. Org. Chem.40(19):2743-8 (1975).
Zhou, Hai-Bing, et al., “Design, synthesis and structure of new chiral squaric acid monoaminoalcohols and diaminoalcohols and their use as catalysts in asymmetric reduction of ketones and diketones,”Tetrahedron57:9325-9333 (2001).
Jeanette Henry C.
Meade Eric A.
Schering Corporation
Willis Douglas M
Wilson James O
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