Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-03-29
2011-03-29
Krass, Frederick (Department: 1612)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C435S007230
Reexamination Certificate
active
07915294
ABSTRACT:
A method is disclosed for detecting colorectal carcinoma having at least one HERG potassium ion channel, where at least one HERG potassium channel is detected in a tissue biopsy of the human color or rectum. In addition, a method is disclosed for treating colorectal carcinoma having at least one HERG potassium channel in a patient in need of said treatment, which comprises the step of administering to said patient, a therapeutically effective amount of 4-[1-{2-(6-methyl-2-pyridinyl)ethyl-4-piperidinyl}carbonyl]methane-sulfoanilide 2HCl sufficient to treat the colorectal carcinoma having at least one HERG potassium channel by selectively blockading the HERG potassium channel.
REFERENCES:
patent: 6071720 (2000-06-01), Hillman et al.
Bianchi et al., herg Encodes a K+ Current Highly Conserved in Tumors of Different Histogenesis: A Selective Advantage for Cancer Cells, Cancer Research, 1998, 58, p. 815-822.
Wang et al., Modulation of HERG affinity for E-4031 by [K+] and C-type inactivation, FEBS Letters, 1997, 417, pp. 43-47.
Cherubini et al: “HERG Potassium Channels Are More Frequently Expressed in Human Endometrial Cancer As Compared to Non-Cancerous Endometrium” Br.J. Cancer 2000, December 83(12):1722-9.
Krass Frederick
Myers Jonathan
Sutton Darryl C
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