Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1981-02-24
1983-11-15
Gerstl, Robert
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
424244, C07D22508, A61K 31355
Patent
active
044154950
ABSTRACT:
The present invention provides 5,6;8,9-tetrahydro-7H-dibenz(d,f)azonine derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2, which are the same or different, are hydrogen or halogen atoms or lower alkyl or alkoxy radicals, R.sup.3 is a hydrogen atom or a lower alkyl radical, R.sup.4 is a hydrogen atom or a lower alkyl or alkanoyl radical and n is 1 or 2; and the pharmaceutically acceptable salts thereof formed with inorganic and organic acids; but excluding 6-benzyl-2,12-dimethoxy-1-hydroxy-7-methyl-5,6;8,9-tetrahydro-7H-dibenz(d, f)azonine in which case R.sup.1, R.sup.2 and R.sup.4 are hydrogen, n is 1 and R.sup.3 is methyl. The lower alkyl, alkanoyl and alkoxy radicals are straight chained or branched radicals containing 1 to 5 carbon atoms.
The present invention also provides a process for the preparation of these compounds, as well as pharmaceutical compositions containing them.
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J. Amer. Chem. Soc., 80, 445-451, (1958).
J. Amer. Chem. Soc., 89, 2464-2469, (1967).
Kotera, et al., Shionogi Kenyushu Nempo, 17, 88-106 (1967) [Chemical Abstract, 68, 105398t, (1968)].
Bahrmann Heinrich
Fritschi Edgar
Ganser Volker
Herrmann Manfred
Satzinger Gerhard
Gerstl Robert
Godecke Aktiengesellschaft
Patton Walter
Springer D.
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