5,10,-methylene-tetrahydrofolate as a modulator of a chemotherap

Details 5,10,-methylene-tetrahydrofolate as a modulator of a chemotherap 5,10,-methylene-tetrahydrofolate as a modulator of a chemotherap

1994-10-20

1996-07-09

Criares, Theodore J.

Tools

A61K 31505

Patent

active

055345190

ABSTRACT:
The present invention relates to the compound 5,10-methylene-tetrahydrofolate (CH.sub.2 FH.sub.4), and its solution product isomer FH.sub.4, therapeutic uses of these compounds, and compositions thereof. CH.sub.2 FH.sub.4 and FH.sub.4 strongly modulate the in vivo antitumor effects of 5-Fluorouracil.

REFERENCES:
Carter et al; Chemotherapy of Cancer, (Second Edition) pp. 361-365 C 1981.

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