4H-triazolo[4,3-a][1,4]benzodiazepines

Details 4H-triazolo[4,3-a][1,4]benzodiazepines 4H-triazolo[4,3-a][1,4]benzodiazepines

1990-03-08

1991-01-22

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540563, C07D48704, A61K 3155

Patent

active

049871315

ABSTRACT:
Novel 4H-triazolo[4,3-a][1,4]benzodiazepines of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms and R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are individually selected from the group consisting of hydrogen, --OH, alkyl and alkoxy of 1 to 4 carbon atoms, --NH.sub.2, --NHalk wherein alk is alkyl of 1 to 4 carbon atoms, ##STR2## and alk.sub.1 and alk.sub.2 are individually alkyl of 1 to 4 carbon atoms, halogen, --NO.sub.2 and --CF.sub.3 in any position of the benzene rings with the proviso that R.sub.5 and R.sub.6 are not both hydrogen and their non-toxic, pharmaceutically acceptable acid addition salts having good analgesic activity.

REFERENCES:
patent: 3734922 (1973-05-01), Hester
patent: 3880877 (1975-04-01), Sillstedt et al.

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