48 kD cellular phosphoprotein CtBP

Details 48 kD cellular phosphoprotein CtBP 48 kD cellular phosphoprotein CtBP

1995-11-06

1998-06-30

Achutamurthy, Ponnathapura

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

436536, 530350, C07H 2104, G01N 33536, C07K 1400

Patent

active

057735999

ABSTRACT:
Cloning of the cDNA for CtBP via yeast two hybrid interaction cloning. The DNA encodes a 439 amino acid (48 kD) protein that specifically interacts with exon 2. This protein requires residues 225-238 of the 243R E1A protein for interaction. The predicted protein sequence of the isolated cDNA is identical to amino acid sequences obtained from peptides prepared from biochemically purified CtBP. Fine mapping of the CtBP-binding domain revealed that a six amino acid motif highly conserved among the E1A proteins of various human and animal adenoviruses is required for this interaction.

REFERENCES:
Boyd et al. EMBO J vol. 12, No. 2, pp. 469-478, 1993.
PNAS USA vol. 92, No. 23, Nov. 7, 1995, pp. 10467-10471.

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