DNA encoding pertussis toxin muteins

Details DNA encoding pertussis toxin muteins DNA encoding pertussis toxin muteins

1995-06-06

1998-06-30

Ketter, James

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 693, 4242401, C07H 2104, C12N 1531, A61K 3910

Patent

active

057736006

ABSTRACT:
The development of subunits and subunit analogs of the Bordetella exotoxin by recombinant DNA techniques provides vaccine products that retain their biological activity, are highly immunogenic, and can confer protection against disease challenge. Genetically-engineered modifications of the subunits can result in products that retain immunogenicity, yet are free of enzymatic activity associated with toxin of reactogenicity.

REFERENCES:
Nicosia et al., Proc. Natl. Acad. Sci. USA, vol. 83, pp. 4631-4635 (1986).
Zucker et al., Molecular Immunology, vol. 21, No. 9, pp. 785-792 (1984).
Shortle et al., Annual Review of Genetics, vol. 15, pp. 265-292 (1981).
Chen et al., J. Bacteriol., vol. 161, No. 2, pp. 758-763 (1985).
Locht et al., Science, vol. 232, pp. 1258-1264 (1986).
Engstrom et al., FEMS Microb. Letters, vol. 36, pp. 219-223 (1986).
Barbieri et al., Infection and Immunity, vol. 55, No. 5, pp. 1321-1323 (1987).
Nicosia et al. Expression and immunological properties of the five subunits of pertussis toxin. Infection and Immunity vol. 55 963-967, 1987.

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