4-substituted azetidinones as precursors to 2-substituted-3-carb

Details 4-substituted azetidinones as precursors to 2-substituted-3-carb 4-substituted azetidinones as precursors to 2-substituted-3-carb

1993-12-07

1994-12-06

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540302, C07D20508, C07D47700, C07D40906, C07D46300

Patent

active

053712153

ABSTRACT:
New 4-substituted azetidinones having the formulae I and II: ##STR1## wherein X is oxygen, sulfur or a moiety of the formula NR.sup.6 where R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are defined hereafter, which are intermediates for the preparation of carbapenem and carbacephem antibacterials and processes for producing such antibacterials through the utilization of an acid mediated ring closure reaction.

REFERENCES:
patent: 4350631 (1982-09-01), Christensen
patent: 5149802 (1992-09-01), Yoshioka
patent: 5177074 (1993-01-01), Allen, Jr.
Wasserman et al., Tetrahedron Letters, 25:3747-3750 (1984).

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