4-(N-substituted amino)-2-butynyl-1-ureas and thioureas and deri

Details 4-(N-substituted amino)-2-butynyl-1-ureas and thioureas and deri 4-(N-substituted amino)-2-butynyl-1-ureas and thioureas and deri

1989-08-02

1991-01-29

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514331, 514428, 514588, 540610, 544162, 544400, 546247, 548567, 548953, 548966, 564 30, 564 57, 564 59, C07C27520, A61K 3117, C07D245145

Patent

active

049886886

ABSTRACT:
4-(N-Substituted amino)-2-butynyl-1-ureas and thioureas and derivatives thereof are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as centrally acting muscarinic agents and are useful as analgesic agents for the treatment of pain, as sleep aids and as agents for treating the symptoms of senile dementia, Alzheimer's disease, Huntington's chorea, tardive dyskinesia, hyperkinesia, mania, or similar conditions of cerebral insufficiency characterized by decreased cerebral acetylcholine production or release.

REFERENCES:
patent: 3354178 (1967-11-01), Dickinson
patent: 4065471 (1977-12-01), Dickinson
Ferrand, European J. Med. Chem. Chim. Ther. 11, 49 (1976) Abstract only.
Journal of Medicinal Chemistry, 10:615 (1967) Neumeyer, et al, Pharmacologically Active Acetylene Compounds.I. Structural Modifications of Oxotremorine.
Brit. J. Pharmacol. (1966), 26, 56-67 A. Bebbington, et al, The Central and Peripheral Activity of Acetylenic Amines related to Oxotremorine.

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