4-hydroxypiperidine derivatives having analgesic activity

Details 4-hydroxypiperidine derivatives having analgesic activity 4-hydroxypiperidine derivatives having analgesic activity

2005-10-18

2005-10-18

Trinh, Ba K. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S216000, C546S184000, C546S192000, C546S220000

Reexamination Certificate

active

06956046

ABSTRACT:
A compound represented by the following Formula (I):(wherein A represents oxygen atom or —NR3— (R3represents hydrogen atom or lower alkyl group); R1represents nitro group, lower alkoxycarbonyl group, carbamoyl group unsubstituted or mono- or di-substituted by lower alkyl group, unprotected or protected hydroxyl group, unprotected or protected carboxyl group, lower alkyl group substituted by unprotected or protected hydroxyl group, or tetrazolyl group; and R2represents hydrogen atom, cyano group or lower alkylsulfonyl group, provided that when A is —NR3—, it is excluded that R1represents unprotected or protected hydroxyl group or lower alkyl group substituted by unprotected or protected hydroxyl group) or its salt, and method for producing the compound, and a pharmaceutical composition containing the compound as active ingredient.

REFERENCES:
patent: 6255322 (2001-07-01), Welch
patent: 6642257 (2003-11-01), Yamamoto et al.

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