4-fluoroalkyl-substituted benzoylguanidines, process for their p

Details 4-fluoroalkyl-substituted benzoylguanidines, process for their p 4-fluoroalkyl-substituted benzoylguanidines, process for their p

1998-06-22

2000-12-05

Kumar, Shailendra

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514309, 514312, 514345, 514398, 514424, 546134, 546141, 546290, 5483351, 548541, 564134, 564162, 564237, A61K 31165, C07C27922

Patent

active

061568007

ABSTRACT:
There are described benzoylguanidines of the formula I ##STR1## where R(1) is R(4)--SO.sub.m, R(5)R(6)N--SO.sub.2 --; O.sub.p --(CH.sub.2).sub.q --(CF.sub.2).sub.r --CF.sub.3 ; --SR(10), --OR(10) or --CR(10)R(11)R(12); R(2) is --(CH.sub.2).sub.u --(CF.sub.2).sub.t --CF.sub.3 ; R(3) is hydrogen or independently defined as R(1); and their pharmaceutically tolerable salts. They are obtained by reaction of a compound of the formula II ##STR2## with guanidine. They are compounds of outstanding activity on the cardiovascular system.

REFERENCES:
patent: 3780027 (1973-12-01), Cragoe et al.
patent: 5091394 (1992-02-01), Englert et al.
patent: 5373024 (1994-12-01), Lang et al.
English Abstract for EP 0 754 680 A1 (Derwent Abstract No. 97-089242).

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