4-Desoxy-4-epipodophyllotoxin derivative or pharmaceutically acc

Details 4-Desoxy-4-epipodophyllotoxin derivative or pharmaceutically acc 4-Desoxy-4-epipodophyllotoxin derivative or pharmaceutically acc

1995-01-13

1996-02-06

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49304

Patent

active

054896983

ABSTRACT:
A 4-desoxy-4-epipodophyllotoxin derivative of the following formula ##STR1## wherein R and R.sub.1 are as defined in the specification or a pharmaceutically acceptable salt thereof as well as an antitumor composition comprising such derivative or salt as an active ingredient.

REFERENCES:
Chemical Abstracts, vol. 112, No. 1, 1 Jan. 1990, JP-A-1 117 885.
Chemical Abstracts, vol. 115, No. 19, 11 Nov, 1991, JP-A-3 127 792.
Podophyllotoxin Analogs: Effects on DNA Topoisomerase II, Tubulin Polymerization, Human Tumor KB Cells, and Their VP-16-Resistant Variants Molecular Pharmacology, (36), pp. 78-82, 1989.

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