4-Carbamoylamino-.alpha.-aminomethylbenzyl alcohol derivatives

Details 4-Carbamoylamino-.alpha.-aminomethylbenzyl alcohol derivatives 4-Carbamoylamino-.alpha.-aminomethylbenzyl alcohol derivatives

1977-06-27

1979-03-20

Waltz, Thomas

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260553C, 424322, C07C12717, A61K 3117

Patent

active

041453638

ABSTRACT:
There are disclosed novel 4-substituted amino-.alpha.-aminomethylbenzyl alcohol derivatives represented by the formula: ##STR1## wherein X represents a halogen atom; Y represents a hydrogen atom or a halogen atom; R.sub.1 represents a lower alkyl group, a carbamoyl group, a mono- or di-lower alkyl-substituted carbamoyl group, a phenyl-substituted carbamoyl group, a lower alkoxycarbonyl group, a lower alkoxy-substituted lower alkoxycarbonyl group, a phenyl-substituted lower alkoxycarbonyl group, or a cycloalkyloxycarbonyl group; and R.sub.2 represents a lower alkyl group, a cycloalkyl group, or the group shown by the ##STR2## wherein R.sub.3 represents a hydrogen atom or a lower alkyl group and R.sub.4 represents a hydrogen atom, a hydroxy group, or a lower alkoxy group and the pharmaceutically acceptable nontoxic salts thereof.
These compounds are antiasthmatic agents useful for the prophylaxis and treatment of asthma.

REFERENCES:
patent: 3644520 (1972-02-01), Hartley et al.
patent: 3689524 (1972-09-01), Jack et al.
patent: 3930016 (1975-12-01), Berntsson et al.
patent: 3935259 (1976-01-01), Wilhelm
patent: 3944611 (1976-03-01), Smith
patent: 3959369 (1976-05-01), Smith
patent: 3998790 (1976-12-01), Brandstrom et al.
patent: 4015011 (1977-03-01), Schromm et al.
patent: 4041075 (1977-08-01), Smith

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