4-arylmethyl-5-alkyl-3h-pyrazol-3-ones

Details 4-arylmethyl-5-alkyl-3h-pyrazol-3-ones 4-arylmethyl-5-alkyl-3h-pyrazol-3-ones

1992-08-19

1993-03-16

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514404, 544353, 5483644, 5483647, 5483061, A61K 31415, A61K 31495, C07D40302, C07D40502

Patent

active

051944359

ABSTRACT:
The compounds of the formula: ##STR1## in which the dotted lines represent optional unsaturation when n is 1 or 2 and X is CR.sup.5, Y is CR.sup.6 or X or Y are N; R.sup.1 is hydrogen, alkyl, aryl or arylalkyl; R.sup.2 is hydrogen, alkyl, aryl or arylalkyl; R.sup.3 is alkyl, perfluoromethyl or alkoxy; R.sup.4 is halogen, alkyl or alkoxy; X is CR.sup.5, O, S or N, in which R.sup.5 is hydrogen, halogen, alkyl, or alkoxy; Y is CR.sup.6, O, S or N, in which R.sup.6 is hydrogen, halogen, alkyl or alkoxy; n is one of the integers 0, 1 or 2; m is one of the integers 0, 1, 2, or 3; or a pharmaceutically acceptable salt thereof, with the provisos that one of X and Y is O,S or N and R.sup.3 is other than alkyl when n and m are 0 and X and Y are O, are useful hypolglycemic agents in the treatment of non-insulin dependent diabetes melitus.

REFERENCES:
Boots et al., Chemical Abstracts, vol. 67 (1967) No. 32651n.

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