Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1974-05-28
1976-09-07
Todd, G. Thomas
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260239B, 260247, 2602472B, 2602472A, 260268R, 26029362, 26029372, 26029381, 26029384, 26032643, 2603265R, 2603268, 2605705CA, 424244, 424248, 424250, 424267, 424274, 424311, 424325, C07C 9318
Patent
active
039794440
ABSTRACT:
The invention relates to novel 4-hydroxymethyl(acyloxymethyl and methyl)-4-arylcyclohexylamines embraced by the formula ##SPC1##
Wherein Ar is an aromatic ring selected from the group consisting of phenyl and naphthyl, each of which has from zero through three substituents independently selected from the group consisting of fluorine, chlorine, bromine, lower alkyl of one through three carbon atoms, lower alkoxy of one through three carbon atoms, and lower alkylthio of one through three carbon atoms; Z is selected from the group consisting of hydrogen, hydroxy and lower acyloxy of one through four carbon atoms; .about. is a generic expression denoting cis and trans stereoconfiguration and mixtures thereof, with the proviso that when the stereoconfiguration of the linkage connecting the cyclohexane ring and CH.sub.2 Z is cis to the amino group, the linkage connecting the cyclohexane and Ar rings is trans, and vice versa; R.sup.1 is selected from the group consisting of hydrogen and lower alkyl of one through three carbon atoms; R.sup.2 is selected from the group consisting of hydrogen, lower alkyl of one through three carbon atoms, ##EQU1## WHEREIN N IS 2 THROUGH 5 AND Ar has the same meaning as above; R.sup.1 and R.sup.2 taken together with --N< is a saturated heterocyclic amino radical selected from the group consisting of unsubstituted and substituted pyrrolidino, piperidino, hexamethylenimino, morpholino and piperazino; and pharmacologically acceptable acid addition salts thereof. It also relates to intermediates and processes for the preparation of the aforesaid novel compounds (I) and novel derivatives thereof. The administration to humans and animals of the novel compounds (I) depresses their central nervous systems and lowers their blood pressures.
REFERENCES:
patent: 3365451 (1968-01-01), Brannock et al.
patent: 3652589 (1972-03-01), Flick et al.
patent: 3850935 (1974-11-01), Nakao et al.
Jameson William G.
Saliwanchik Roman
The Upjohn Company
Todd G. Thomas
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