4-aryl- and 4-arylthio-5-hydroxy-2(5H)-furanones as inhibitors o

Details 4-aryl- and 4-arylthio-5-hydroxy-2(5H)-furanones as inhibitors o 4-aryl- and 4-arylthio-5-hydroxy-2(5H)-furanones as inhibitors o

1993-12-22

1995-11-07

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549314, 549315, A61K 3134

Patent

active

054648653

ABSTRACT:
The invention provides novel 5-hydroxy-4-aryl- and 5-hydroxy-4-(arylthio)-2(5H)-furanones of the following structure: ##STR1## wherein R contains from about five to about twenty carbon atoms and is defined herein; X is oxygen, sulfur, SO.sub.2, NH, N(lower alkyl), N(lower acyl), aminocarbonyl, carbonyl, carbonylamino, CH.sub.2 or a carbon-carbon bond; Y is hydrogen, halogen, lower alkyl, nitro, alkylthio, perfluoroalkyl, hydroxy, or lower alkoxy(C.sub.1 -C.sub.8); Z is sulfur or a carbon-carbon bond; and Q is H, an alkyl of from 1-20 carbon atoms, COR', COOR', CONHR', PO(OR')2, PO(OR')R" wherein R' and R" are independently selected from the group consisting of H, an alkyl of from 1-20 carbon atoms, phenyl, and substituted phenyl and prodrugs thereof and pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprising these compounds, methods of using these compounds as inhibitors of inflammation and for treating other diseases characterized by the overproduction of arachidonic acid metabolites, intermediates and methods of preparing these compounds are also provided.

REFERENCES:
patent: 4874782 (1989-10-01), Bonjouklian et al.
patent: 5037811 (1991-08-01), Lee
patent: 5134128 (1992-07-01), Lee et al.
patent: 5183906 (1993-02-01), Lee et al.

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