4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyr

Details 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyr 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyr

1995-05-23

1997-01-14

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544262, C07D23970, A61K 31415

Patent

active

055939970

ABSTRACT:
Certain 4-aminopyrazolo[3,4-d]pyrimidine compounds, and their pharmaceutically-acceptable salts and prodrugs, are inhibitors of tyrosine kinase enzymes and are useful for immunoregulation and for the treatment of cancer, angiogenesis and atherosclerosis.

REFERENCES:
patent: 4044130 (1977-08-01), Howarth et al.
Tominaga, Y, "Synthesis . . . ", Journal of Heterocylic Chem., 27, 647-60, (1989).
Gatta, F., "Pyrazolo . . . ", J. Heterocyclic Chem., 26, 613 (1989).
Tominaga, Y, "Synthesis . . . ", Journal of Heterocyclic Chem., 27, 647-60, (1989).

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