4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones

Details 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones

1981-05-04

1983-04-26

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544365, 544124, 544139, 546193, 546210, 546278, 548318, 548321, C07D40300, C07D40100, C07D23330

Patent

active

043813933

ABSTRACT:
1,3-Dihydro-2H-imidazol-2-ones having 5-acyl and 4-(substituted amino)methyl substituents, are useful as cardiotonics, antihypertensives and antithrombotic agents. The compounds are obtained by the reaction of an appropriate amine with a substituted 4-bromomethyl-1,3-dihydro-2H-imidazol-2-one.

REFERENCES:
patent: 2441933 (1945-07-01), Duschinsky
patent: 2514380 (1946-12-01), Duschinsky
patent: 3303199 (1967-02-01), Doebel et al.
patent: 3365450 (1968-01-01), Lunsford et al.
Duschinsky et al., J. Am. Chem. Soc., 68 2350, (1946).
Duschinsky et al., J. Am. Chem. Soc. 70, 657 (1948).
Dage et al., Fed. Proc. 39:1105 (1980) Abstract.
Boularand et al., Chimie Ther. 8, 638 (1973).

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