4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivatives...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C540S593000

Reexamination Certificate

active

10495494

ABSTRACT:
4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivatives, which have excellent arginine vasopressin V2activity and are useful for a drug for the treatment of central diabetes insipidus and/or nocturia.

REFERENCES:
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patent: 5753644 (1998-05-01), Ogawa et al.
patent: 6096736 (2000-08-01), Ogawa et al.
patent: 6340678 (2002-01-01), Matsuhisa et al.
patent: 09-221475 (1997-08-01), None
Kondo et al., Novel Design of Nonpeptide AVP V2 Receptor Agonists: Structural Requirements for an Agonist Having 1-(4-Aminobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine as a Template, J. of Medicinal Chemistry, Nov. 2000, vol. 43, No. 23, pp. 4388-4397.

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