Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1996-10-11
1998-06-02
Dees, Jose G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
514260, C07D23900, A61K 31505
Patent
active
057602301
ABSTRACT:
4,4'-Bridged bis-2,4-diaminoquinazolines of the general formula (I) ##STR1## processes for their preparation and use as agents acting on the potassium channels of the brain.
REFERENCES:
Yu et al., (CA AN 1993:551627, Bioorg. Med. Chem. Lett. (1992), 2(9), 1121-6).
Ding et al., (AN 1985:160042, Shanghai Inst. Pharm. Ind., Shanghai, Peop. Rep. China).
Hynes et al., (AN 1973:52530, J. Med. Chem. (1972), 15(12), 1332-3).
Zhang et al., (AN 1989:33336, Yiyao Gongye (1988), 19(9), 396-400).
Haberman et al., "Bee Venom Neurotoxin (Apamin): Iodine Labeling and Characterization Binding Sites," Eur.J.Biochem. 94, 355-364 (1979).
Mourre et al., "Quantitative Autoradiographic Mapping in Rat Brain of the Receptor of Apamin, a Polypeptide Toxin Specific for One Class of Ca.sup.2+ -dependent K.sup.+ Channels," Brain Research, 382, 239-249 (1986).
Heurteaux et al., "Memory processing and apamin induce immediate early gene expression in mouse brain," Molecular Brain Research, 3, 17-22 (1993).
Messier et al., "Effect of apamin, a toxin that inhibits Ca.sup.2+ -dependent K.sup.+ channels, on learning and memory processes," Brain Research, 551, 322-326 (1991).
Behrens et al., "Possible Role of Apamin-Sensitive K.sup.+ Channels in Myotonic Dystrophy," Muscle & Nerve, 1264-1270 (1994).
"Depression: a new animal model sensitive to antidepressant treatments," Nature, 266, 730-732 (1977).
Morris, "Developments of a water-maze procedure for studying spatial learning in the rat," Journal o Neuroscience Methods, 11, 47-60 (1984).
Bullock William
Chisholm Jane C.
Fanelli Richard J.
Feurer Achim
Lerchen Hans-Georg
Bayer Aktiengesellschaft
Dees Jos,e G.
Qazi Sabiha N.
LandOfFree
4, 4'-bridged bis-2, 4-diaminoquinazolines does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 4, 4'-bridged bis-2, 4-diaminoquinazolines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4, 4'-bridged bis-2, 4-diaminoquinazolines will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1461506