(-) 4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl!-h

Details (-) 4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl!-h (-) 4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl!-h

1995-05-31

1996-04-30

Daus, Ronald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C07D 3714

Patent

active

055125719

ABSTRACT:
Diastereomeric intermediate salts of formulae (IIIa) or (IIIb) ##STR1## are prepared.

REFERENCES:
patent: 4521415 (1985-06-01), Katakami et al.
patent: 4843072 (1989-06-01), Yasuda et al.
patent: 4914093 (1990-04-01), Morisawa et al.
patent: 4946842 (1990-08-01), Coates et al.
patent: 5019575 (1991-05-01), Haikala et al.
patent: 5151420 (1992-09-01), Backstrom et al.
J. Org. Chem. 1991, 56, 1963-1966, An Enantioselective synthesis of SK&F 93505, A Key Intermediate for Preparing Cardiotonic Agents by Franklin F. Owings, Margaret Fox, Conrad J. Kowalski, and Neil H. Baine.
"Synthesis and Biological Activity of Four Stereoisomers of 6- 4- 3- 2 Hydroxy-3- 4- 2-(Cyclopropylmethoxy)ethyl!phenoxyl!propl!amino !-propionamide!phenyl!-5-methyl-4,5-dihydro-3(2H)-pyridazinone, a Combined Vasodilator and .beta.-Adrenoceptor Antagonist", W. Howson et al., J. Med. Chem. 1988, vol. 31, pp. 352-356.

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