[3R]-3-amino-1-hydroxy pyrrolidin-2-one and its use as a neuropr

Details [3R]-3-amino-1-hydroxy pyrrolidin-2-one and its use as a neuropr [3R]-3-amino-1-hydroxy pyrrolidin-2-one and its use as a neuropr

1988-11-18

1989-09-05

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548542, C07D207273, A61K 3140

Patent

active

048639532

ABSTRACT:
The present invention provides R(+)-3-amino-1-hydroxypyrrolidin-2-one of formula I: ##STR1## or pharmaceutically acceptable acid addition salt thereof, which compound is useful as an anticonvulsant agent and in the treatment and/or prevention of neurodegenerative disorders.

REFERENCES:
Evans et al., Brain Research, 1978, 148, 536-542.
Barlos et al [C.A., 110(5):39341b] Liebigs Ann. Chem. (12) 1127-33 (1988).
Olverman [CA 109(19):163649b] Neuroscience (Oxford), 26 (1) 17-31 1988.
Foster et al [C.A., 96(17) 136522m]Br. J. Pharm., 74(3) 723-9 (1981).
Dimoto et al [CA 95(7):57583h] J. Biol. Chem., 256(10), 5134-43 (1981).

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