Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-09-13
2005-09-13
Parkin, J. S. (Department: 1648)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C424S228100
Reexamination Certificate
active
06943246
ABSTRACT:
The invention relates to the discovery of a novel RNA sequence at the 3′ terminal sequence of hepatitis C virus (HCV) genome RNA. Included in the invention are the 3′ sequence, its complement, and their use for nucleic-acid based diagnostics and for developing and evaluating novel anti-HCV therapies. This sequence element, which is conserved among HCV genotypes, is likely to be essential for viral replication, and required for construction of full-length HCV cDNA clones capable of yielding infectious RNA, progeny virus or replication-competent HCV replicons. Such functional clones are useful tools for evaluation of therapeutic approaches and as substrates for developing candidate attenuated or inactivated HCV derivatives for vaccination against HCV.
REFERENCES:
patent: 5698390 (1997-12-01), Houghton et al.
patent: 5714596 (1998-02-01), Houghton et al.
patent: 510952 (1992-10-01), None
patent: 521318 (1993-01-01), None
patent: 645451 (1995-03-01), None
patent: WO 93/03186 (1993-02-01), None
Han et al., Characterization of the terminal regions of hepatitis C viral RNA: Identification of conserved sequences in the 5′ untranslated region and poly(A) tails at the 3′ end. Proc. Natl. Acad. Sci. 88:1711-1715, 1991.
Bukh et al., Sem. Liver Dis., 1995, 15: 41-63.
Boyer and Haenni, J. Gen. Virol., 1994, 198: 415-426.
Bresters et al., J. Med. Virol., 1994, 43: 262-268.
Chazouilleres et al., Gastroenterology, 1994, 106:994-999.
Davis et al., Hepatology, 1994, 19: 1337-1341.
Feray et al., Hepatology, 1994, 20: 1137-1143.
Gordon et al., Am. J. Gastroenterol., 1994, 89: 1458-1461.
Lin et al., J. Virol., 1994, 68: 5063-5073.
Okamoto et al, J. Gen. Virol., 1994, 75: 629-635.
Sakamoto et al., J. Gen. Virol., 1994, 75: 1761-1768.
Simmonds et al., J. Gen. Virol., 1994, 75: 1053-1061.
Tokita et al., J. Gen. Virol., 1994, 75: 931-936.
Wright et al., Hepatology, 1994, 20: 773-779.
Chen et al., Virology, 1992, 188: 102-113.
Cha et al., J. Clin. Microbiol. 1991, 29: 2528-2534.
Inchauspe et al., Proc. Natl. Acad. Sci. USA, 1991, 88: 10292-10296.
Mandl et al., Biotechniques, 199, 10: 486.
Okamoto et al., J. Gen. Virol., 1991, 72: 2697-2704.
Chambers et al., Virology, 1990, 177: 159-174.
Sullenger, et al., Cell, 1990, 63: 601-608.
Umlauft et al., Hepatits C Virus Detection by Single-Round PCR Specific for the Terminal 3′ Noncoding Region, J. Clin. Micro., 1996, 34: 2552-2558.
Choo, et al., Proc. Natl. Acad. Sci. USA, 1995, 88: 2451-2455.
Han et al., Proc. Natl. Acad. Sci. USA, 1991, 88: 1711-1715.
Yoo et al., J. Virology, 1995, 69: 32-38.
Hahn et al., J. Mol. Biol., 1987, 198: 33-41.
Kolykhalov et al., J. Virology, 1996, 70: 3363-3371.
Tanaka et al., Biochem. Biophys. Res. Commun., 1995, 215: 744-749.
Tanaka et al., J. Virology, 1996, 70:3307-3312.
Reeck et al., Cell, 1987, 50: 667.
Lewin, Science, 1987, 237: 1570.
Strongin, W., “Sensitivity, Specificity, and Predicitive Value of Diagnostic Tests: Definitions and Clinical Applications”, in Laboratory Diagnosis of Viral Infections, Lennette, E., ed., Marcel Dekker, Inc., New York, 1993, 211-219.
Houghton, M. “Hepatitis C Viruses”, in Fields Virology, Third Edition, Fields, B. N., et al., eds., Lippincott-Raven Publishers, Philadelphia, 1996, 1037.
Roizman, B. and P. Palese, “Multiplication of Viruses: An Overview”, in Fields Virology, Third Edition, Fields, B. N., et al., eds., Lippincott-Raven Publishers, Philadelphia, 1996, 105.
Kolykhalov Alexander A.
Rice Charles M.
Parkin J. S.
Thompson & Coburn LLP
Washington University
LandOfFree
3′terminal sequence of hepatitis C virus genome and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 3′terminal sequence of hepatitis C virus genome and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3′terminal sequence of hepatitis C virus genome and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3437274