3'-sulfonyl nucleoside compounds

Details 3'-sulfonyl nucleoside compounds 3'-sulfonyl nucleoside compounds

1993-11-03

1996-07-16

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2781, 536 285, 536 2854, 536115, C07H 1906, C07H 19073, C07H 1916, C07H 19173

Patent

active

055368239

ABSTRACT:
Analogues of RNA and DNA compounds contain a neutral, stereoregular linking group based on replacement of the phosphoryl with a sulfonyl group. Precursors to the analogues are also described, as are methods for preparing the precursors and analogues.

REFERENCES:
Mirabelli et al., Anti Cancer Drug Design, vol. 6, pp. 647-661, (1991).
Uhlmann et al., Chemical Reviews, vol. 90, No. 4, pp. 544-584, (1990).
Musicki et al., Tetrahedron Letters, vol. 32, No. 10, pp. 1267-1270, (1991).
Reynolds et al., J. Org. Chem., vol. 57, No. 11, pp. 2983-2985 (1992).

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