3-substituted nitro-steroid derivatives as 5-.alpha.-reductase i

Details 3-substituted nitro-steroid derivatives as 5-.alpha.-reductase i 3-substituted nitro-steroid derivatives as 5-.alpha.-reductase i

1989-08-23

1990-11-13

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514176, 514177, 552521, A61K 3156, A61K 3158

Patent

active

049702041

ABSTRACT:
Invented are 3-nitro- substituted steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase including using these compounds to reduce prostate size. Also invented are intermediates used in preparing these compounds.

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Petrow et al., Steroids 38: 121-140 (1981).
Brooks et al., Steroids 47: 1-19 (Jan. 1986).

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