3-Substituted-2(1H)pyridone-6-carboxylic acids

Details 3-Substituted-2(1H)pyridone-6-carboxylic acids 3-Substituted-2(1H)pyridone-6-carboxylic acids

1977-12-28

1979-05-29

Raymond, Richard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

546296, A61K 3144, A61K21379

Patent

active

041567285

ABSTRACT:
Novel compounds useful as hypotensive agents are presented having the general formula I ##STR1## wherein R.sub.1 represents a substituted or unsubstituted aralkyl group, that is an aralkyl group of the general formula ##STR2## wherein R.sub.2 represents hydrogen, a lower alkyl group or a halogen atom. Furthermore, new therapeutic compositions of matter are also described incorporating the above novel 3-substituted-2(1H)pyridone-6-carboxylic acids (I) as an active ingredient with carriers and showing uses as hypotensive agents. These new compounds of the formula I are prepared by reacting D-glucaro-.delta.-lactam or its salt with an aralkyl halide.

REFERENCES:
patent: 3355278 (1967-11-01), Weil et al.
Kametani et al., Chemical Abstracts, vol. 74 (1971), 13311e.
Stetter et al., Chemical Abstracts, vol. 52 (1958), 91290.

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