3-Substituted-1-aryl-2(1H)-quinolones useful as anti-allergy and

Details 3-Substituted-1-aryl-2(1H)-quinolones useful as anti-allergy and 3-Substituted-1-aryl-2(1H)-quinolones useful as anti-allergy and

1991-07-19

1994-06-07

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514269, 514312, 544238, 544328, 544331, 544405, 546155, 546157, A61K 3147, C07D215227

Patent

active

053189710

ABSTRACT:
Novel 3-substituted-1-aryl-2(1H)-quinolones useful as anti-allergy, anti-inflammatory, anti-hyperproliferative skin disease agents are disclosed. The quinolones are represented by Formula 1: ##STR1## Pharmaceutical compositions and methods of treatment employing such compounds are also disclosed.

REFERENCES:
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patent: 4735948 (1988-04-01), Wright
patent: 4748246 (1988-05-01), Skotnicki et al.
patent: 5008274 (1991-04-01), Nishi et al.
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Meth-Cohn et al., J. C. S. Perkin I 1520 (1981).
Chemical Abstract 211280h, vol. 91, No. 26 (Dec. 24, 1979) and Reg. No. 71978-18-2 (Jun. 13, 1979); and Derwent Abstract 55102b.
Chemical Abstract 221701e, vol. 108, No. 25 (Jun. 20, 1988), and Reg. No. 114560-96-2 and Reg. No. 114560-71-3 (Oct. 21, 1987).
Chemical Abstract 204453h, vol. 18, No. 14, (Apr. 4, 1988), and Reg. No. 114125-87-0.
Chupp and Metz, Heterocycles from Substituted Amides, VI (1,2).
J. Heterocyclic Chem., 16, pp. 65-71, 1979.
Chemical Abstract 92023s, vol. 79, 1973.

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