(3-Piperazinocarbonylimino-quanidino)-isoxazoles

Details (3-Piperazinocarbonylimino-quanidino)-isoxazoles (3-Piperazinocarbonylimino-quanidino)-isoxazoles

1977-09-20

1978-07-25

Tovar, Jose

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260307H, 26029358, 544137, 544367, C07D41312

Patent

active

041030109

ABSTRACT:
The present invention relates to compounds having the general formula: ##STR1## in which R.sub.1 and R.sub.2, which may be the same or different, represent each a hydrogen atom, a C.sub.1 -C.sub.6 alkyl radical or a C.sub.3 -C.sub.6 cycloalkyl radical; R.sub.3 represents a hydrogen atom or a C.sub.1 -C.sub.4 alkyl radical; R.sub.4 and R.sub.5, which may be the same or different, represent a hydrogen atom, a C.sub.1 -C.sub.6 alkyl radical or, together with the nitrogen atom to which they are attached, form a pyrrolidino, piperidino, morpholino or piperazinyl radical optionally substituted with a C.sub.1 -C.sub.4 alkyl radical, or a 4-hydroxypiperidino radical, and their pharmaceutically acceptable acid addition salts.
Said compounds are therapeutically useful for the control of the cardio-vascular system and of the blood pressure.

REFERENCES:
patent: 3808224 (1974-04-01), Aron-Samuel
patent: 3950333 (1976-04-01), Durant et al.

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