Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-01-25
1990-04-17
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 61, A61K 31435, C07D22118
Patent
active
049180770
ABSTRACT:
Dihydrobenz[c]acridine carboxylic acid derivatives are provided which are useful in treating tumors in mammals. These dihydrobenz[c]acridine carboxylic acid derivatives have the formula: ##STR1## or a pharmaceutically acceptable salt thereof, where R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined in the specification. Also provided are pharmaceutical compositions of said compounds. In addition, processes for the preparation of these compounds are disclosed.
REFERENCES:
patent: 2579420 (1951-12-01), Coles
patent: 4680299 (1987-07-01), Hesson
Cromwell et al., "5,6-Dimeth. benz[c]acnidine Functionalized in 7-Position", Journ. Het. Chem. vol. 16, pp. 699-704 (1979).
Bell et al., "Benzacridines. Synth. and Reactions", Journ. Org. Chem. vol. 23, pp. 789-793 (1958).
Cromwell et al., "Benzacridines Synthesis", Journ. Org. Chem., vol. 24, pp. 1077-1080, (1959).
Buu-Hoi et al., J. Chem. Soc. pp. 5622-5626 (1964).
Buu-Hoi et al.; Chem. Abstr. 40:2816 (1944).
Cromwell et al. (J. Org. Chem. 23, 789-793 (1958).
Braunholtz et al. (J. Chem. Soc. 3368-3377 (1958).
Buu-Hoi et al. (J. Chem. Soc. 2274-2279 (1963).
Sy et al. (Bull. Chim. Soc. Fr. 1308-1315 (1965)).
Al-Tai et al. (J. Chem. U.A.R. 10, 339-352 (1967)).
Cagniant et al. (Bull. Soc. Chim. Fr. 3, 985-991 (1969)).
Rosowsky et al. (J. Heterocycl. Chem. 8, 809-820 (1971)).
Cromwell et al. (J. Heterocycl. Chem. 16, 699-704 (1979)).
Yamaguchi et al., J. Heterocyclic Chem., 26, 285-7 (1989).
E. I. Du Pont de Nemours & Co., (Inc.)
Rozycki Andrew G.
Shah Mukund J.
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