3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S212080, C514S218000, C540S492000, C540S524000, C540S527000

Reexamination Certificate

active

06953788

ABSTRACT:
The present invention relates to certain novel 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase. Pharmaceutical compositions containing said compounds as well as methods of treating various disease states responding to inhibition of matrix metalloproteinase are also claimed herein.

REFERENCES:
patent: 4599361 (1986-07-01), Dickens et al.
patent: 4681966 (1987-07-01), Donald et al.
patent: 4771038 (1988-09-01), Wolanin et al.
patent: 4885283 (1989-12-01), Broadhurst et al.
patent: 4935404 (1990-06-01), Hunter et al.
patent: 5238932 (1993-08-01), Flynn et al.
patent: 5239078 (1993-08-01), Galardy et al.
patent: 5252560 (1993-10-01), Myers et al.
patent: 5300501 (1994-04-01), Porter et al.
patent: 5304549 (1994-04-01), Broadhurst et al.
patent: 5310763 (1994-05-01), Campion et al.
patent: 5362750 (1994-11-01), Rosini et al.
patent: 5366973 (1994-11-01), Flynn et al.
patent: 5389628 (1995-02-01), Flynn et al.
patent: 5420271 (1995-05-01), Warshawsky et al.
patent: 5424425 (1995-06-01), Flynn et al.
patent: 5428158 (1995-06-01), Warshawsky et al.
patent: 5430145 (1995-07-01), Flynn et al.
patent: 5455242 (1995-10-01), Warshawsky et al.
patent: 5457196 (1995-10-01), Warshawsky et al.
patent: 5504212 (1996-04-01), de Solmes et al.
patent: 0236872 (1987-09-01), None
patent: 0489579 (1992-06-01), None
patent: 0534363 (1993-03-01), None
patent: 0621270 (1994-10-01), None
patent: 9606890 (1988-09-01), None
patent: 9513289 (1995-05-01), None
patent: 9611209 (1996-04-01), None
patent: 9629313 (1996-09-01), None
patent: 9635687 (1996-11-01), None
patent: 9635711 (1996-11-01), None
patent: 9635714 (1996-11-01), None
patent: 9636227 (1996-11-01), None
patent: 9665712 (1996-11-01), None
patent: 9712861 (1997-04-01), None
patent: 9712902 (1997-04-01), None
patent: 9717088 (1997-05-01), None
patent: 9719075 (1997-05-01), None
Greenwald, Annals of the New York Academy of Sciences 878:413-419 (1999).
McCachren, S.S.Arthritis Rheum.34, pp 1085-1093 (1991).
Emonard, H. et al,Cell Molec. Biol.36, pp 131-153 (1990).
Birkedal-Hansen, H.,J. Oral Pathol.17, pp 445-451 (1988).
Matrisian, L.M.,Trends Genet.6, pp 121-125 (1990).
Murphy, G.J.P. et al,FEBS Lett.289, pp 4-7 (1991.
Matrisian, L.M.,Bioessays14, pp 455-463 (1992).
Swhwartz, G.K. et al,Cancer73, pp 22-27 (1994).
Bernhard, E.J. et al,Proc. Natl. Acad. Sci.91, pp 4293-4597 (1994).
Zucker, S. et al, Cancer Res. 53, pp 140-146 (1993).
Chirivi, R.G.S. et al,Int. J. Cancer58, pp 460-464 (1994).
Montgomery, A.M.P. et al,Cancer Res.54, pp 5467-5473 (1994).
Hasty, K.A. et al,Arthr. Rheum.33, pp 388-397 (1990).
Murphy, G. et al,Biochem. J.248, pp 265-268 (1987).
Gearing, A.J.H. et al,Nature370, pp 555-557 (1994).
Mohler, K.M. et al,Nature370, pp 218-220 (1994).
McGreehan, G.M. et al,Nature370, pp 558-561 (1994).
Wahl, R.C. et al,Annual Reports in Medicinal Chemistry25, pp 177-184 (1990).
Hennney, A.m., et al,Proc. Natl. Acad. Sci.88, pp 8154-8158 (1991).
Burns, F.R. et al,Invest. Opthalmol. and Visual Sci.30, No. 7 pp 1569-1575 (1989).
Overall, C.M. et al,J. Periodontal Res.22, pp 81-88 (1987).
Miyazaki, K. et al,Nature362, pp 839-841 (1993).
Beckett, R.P. et al, “Recent advances in matrix metalloproteinase inhibitor research”DDTvol. 1, No. 1, Jan., 1996, pp 16-26.
Blanchard et al, “Reevaluation of the Absorption of Carbenoxolone Using an In Situ Rat Intestinal Techinque”,Journ. Pharmaceutical Sci.,vol. 79, No. 5, May, 1990 pp 411-414.
Davies, B. et al, “A Synthetic Matrix Metalloproteinase Inhibitor Decreases Tomor Burden . . . ”,Cancer Research53, May 1, 1993, pp 2087-2091.
Hodgson, John, “Remodeling MMPIs”,Bio/Technologyvol. 13, Jun. 1995 pp 554-557.
Chapman, K.T., “Inhibition of Matrix Metalloproteinases . . . ”, J. Med. Chem. 1993, 36, pp 4293-4301.
Beeley N.R.A, “Inhibitors of Matrix Metalloproteinases (MMP's)”, Curr. Opin, Ther. Patents (1994) 4(1), pp 7-16.
Baxter, Andrew D. et al, “A Novel Series of Matrix Metalloproteinase Inhibitors for the Treatment of Inflammatory Disorders”, Bioorganic & Medicinal Chem. Letters, vol. 7, No. 7 pp 897-902, (1997).
CA, Issue 3, pp 16, 126:60361y (1997).
Derwent Abstract 96-035866, Week 9604, WPI Database XP 002046217.
Burkholder, E.A., Bioorg Med Chem Lett, vol. 3, No. 2, 1993, p 231-234, XP002046216.

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