3'-hydroxybenzoxazinorifamycin derivative, process for preparing

Details 3'-hydroxybenzoxazinorifamycin derivative, process for preparing 3'-hydroxybenzoxazinorifamycin derivative, process for preparing

1989-09-14

1991-01-08

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540457, C07D49816, A61K 31535

Patent

active

049836021

ABSTRACT:
A rifamycin derivative having the formula (I): ##STR1## wherein A is a group having the formula: ##STR2## in which R.sup.1 is an alkyl group having 4 or 5 carbon atoms or an alkenyl group having 3 to 5 carbon atoms, or a group having the formula: in which n is 3 or 4; or a pharmaceutically acceptable salt thereof. The rifamycin derivative (I) exhibits a strong antibacterial activity against Gram-positive bacteria and acid-fast bacteria, and also exhibits a strong antibacterial activity against tubercle bacilli.

REFERENCES:
patent: 3338888 (1967-08-01), Bickel et al.
patent: 4005077 (1977-01-01), Bickel et al.
patent: 4690919 (1987-09-01), Yamane et al.
patent: 4859661 (1989-08-01), Kano et al.
Noller "Chemistry of Organic Compounds", Second Edition (1987) (Saunders), p. 170.
Chemical Abstracts, vol. 68, No. 23, Jun. 1968, Abstract No. 104800f.
Chemical Abstracts, vol. 68, Subject Index E-O, Jan.-Jun. 1968, p. 13835, column 3, formula 1, keyword "2,7-(Epoxypentadeca[1,11,13]-trienimino)-6H-benzofuro[4,5-a]phenoxazine-1 ,6,15(2H)-trione".

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