3-Hydroxy-5,6-benzomorphinan derivatives

Details 3-Hydroxy-5,6-benzomorphinan derivatives 3-Hydroxy-5,6-benzomorphinan derivatives

1974-05-06

1976-01-06

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260283SY, 260289R, 260286A, 260348A, 2605705CA, 424260, C07D22122, C07D22128, A61K 31485

Patent

active

039311880

ABSTRACT:
Compounds having the formula ##SPC1##
In which R is cyclopropyl or cyclobutyl have been designated 3-hydroxy-17-substituted-5,6-benzomorphinans. The compounds possess potent narcotic agonist and/or antagonist activity. In particular, the compounds 3-hydroxy-17-cyclopropylmethyl-5,6-benzomorphinan and 3-hydroxy-17-cyclobutylmethyl-5,6-benzomorphinan have been found to possess both activities. These compounds are prepared by total synthesis and are not derived from opium alkaloids.

REFERENCES:
patent: 3329682 (1967-07-01), Bentley
Bentley et al., Proc. Chemical Soc. (London), p. 220, (1963).

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