3-heteroatom containing urea and thiourea ACAT inhibitors

Details 3-heteroatom containing urea and thiourea ACAT inhibitors 3-heteroatom containing urea and thiourea ACAT inhibitors

1991-06-24

1993-02-09

Morris, Patricia L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514252, 514316, 514326, 514384, 5482626, 546187, 546210, 544357, 544366, A61K 3141, C07D24912, C07D24908, C07D40314

Patent

active

051853582

ABSTRACT:
Compounds useful in treating hypercholesterolemia and atherosclerosis having the formula ##STR1## wherein X is oxygen or sulfur, Het is a monocyclic heterocyclic group having three hetero atoms selected from nitrogen, oxygen and sulfur, and R.sub.1, R.sub.2 and R.sub.3 are hydrogen, flourine, chlorine, bromine, a straight or branched alkyl group having from 1 to 6 carbon atoms, a straight or branched alkoxy group having from 1 to 6 carbon atoms, substituted or unsubstituted benzoyl, substituted or unsubstituted benzoyl, substituted or unsubstituted phenyl, amino or substituted amino or a carboxy group.

REFERENCES:
patent: 3836350 (1974-09-01), Fawzi et al.
patent: 3990879 (1976-11-01), Soper
Yakugaku Zasshi 91(2), 159-65 (1971); CA 74:141216q; F. Fujikawa et al., "Studies on Chemotherapeutic Agents. . . ".
Derwent 87-11640/17; "New 2-ureido-1,2,4-thiadiazole derivs-useful as pharmaceutical intermediates. . . " Oct. 15, 1985.

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