Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1978-06-16
1980-02-26
Waltz, Thomas A.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
260558R, 260558D, C07C10376, A61K 31165
Patent
active
041906748
ABSTRACT:
Cinnamamides of formula (I), ##STR1## wherein X is fluoro, chloro, bromo, iodo or trifluoromethyl and R is cycloalkyl or cycloalkyl alkyl, have anticonvulsant properties. The compound trans-3-fluoro-(N-cyclopropyl)cinnamamide is also useful as a muscle relaxant.
REFERENCES:
patent: 3659014 (1972-04-01), Bayssat et al.
patent: 4041071 (1977-08-01), Grivsky
patent: 4053635 (1977-10-01), Gorini et al.
patent: 4091112 (1978-05-01), Grivsky
Szilazyi et al., Acta. Pharm. Hung. 39:66-73 (1969).
Heyningen et al., J. Med. Chem., vol. 9, pp. 675-681 (1966).
Papa et al., J. Amer. Chem. Soc., vol. 72, pp. 3885-3886 (1950).
Shinohara et al., CA 83:109795c (1975).
Brown Donald
Burroughs Wellcome Co.
Waltz Thomas A.
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