3'-expression enhancing fragments and method

Details 3'-expression enhancing fragments and method 3'-expression enhancing fragments and method

1985-03-29

1990-03-20

Mays, Thomas D.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435 691, 435 91, 536 27, 935 39, 935 44, C12N 1500, C12P 2100, C12P 1934, C07H 1512

Patent

active

049101412

ABSTRACT:
The invention concerns a method for extending the half-life of mRNAs. The half-life extension is conferred upon the mRNA by a co-transcribed positive retroregulatory element which is ligated to the 3' end of the DNA sequence encoding the RNA. RNAs having an extended half-life conferred by a co-transcribed positive retroregulatory element are also claimed.

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