Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1983-03-10
1984-09-04
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
536 14, 536 15, 536 16, A61K 3171, C07H 1522
Patent
active
044696833
ABSTRACT:
New semi-synthetic antibiotics, 3"-epistreptomycin and 3"-epidihydrostreptomycin are now provided, which are useful as antibacterial agents. 3"-Epidihydrostreptomycin is produced by a process comprising hydrolyzing an appropriately N,O-protected 2",3"-N,O-carbonyl-3"-epidihydrostreptomycin which is prepared by skilled introduction of amino-protecting groups and hydroxyl-protecting groups of appropriately selected natures into dihydrostreptomycin and intermolecular condensation of a particular pair of amino-protecting and hydroxyl-protecting groups so introduced. 3"-Epistreptomycin is produced by a process comprising oxidizing the 3'-hydroxymethyl group of an appropriately N,O-protected 3"-epidihydrostreptomycin as prepared by skilled introduction of amino-protecting groups and hydroxyl-protecting groups of appropriately selected natures, and then removing the remaining protective groups from the resultant N,O-protected 3"-epistreptomycin obtained as the oxidation product.
REFERENCES:
patent: 2663685 (1953-12-01), Levy
patent: 2790792 (1957-04-01), Kaplan
patent: 2857375 (1958-10-01), Ziegler
patent: 4171356 (1979-10-01), Wright et al.
Sakamoto Shuichi
Shitara Tetsuo
Tsuchiya Tsutomu
Umezawa Hamao
Umezawa Sumio
Brown Johnnie R.
Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
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