Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Plant proteins – e.g. – derived from legumes – algae or...
Patent
1988-09-01
1990-07-03
Schain, Howard E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Plant proteins, e.g., derived from legumes, algae or...
424 91, 530359, 530379, 530406, A61K 3936
Patent
active
049392395
ABSTRACT:
A novel hyposensitization agent was prepared by covalently attaching a saccharide, e.g. homo- and heteroglycans, for example, starch, amylose, dextran, polysucrose, pullulan, elsinan, curdlan, gum arabic, gum tragacanth, guar gum, xanthan gum carrageenan, pectin, cellulose, glucomannan, chitosan, and lipopolysaccharide, and their derivatives and partial hydrolysates to, a cedar pollen allergen. The hyposensitization agent can be administered to a cedar pollinosis patient without fear of eliciting anaphylaxis and allergy within a shortened hyposensitization period because the hyposensitization agent much more enhances the production of immunoglobulin G and M antibodies which are specific to intact cedar pollen allergen, but extremely reduces the production of immunoglobulin E antibody which is specific to the allergen and responsible for anaphylaxis and allergy.
REFERENCES:
patent: 4185090 (1980-01-01), McIntire
patent: 4432969 (1984-02-01), Batchelor
"Isolation and Partial Characterization of the Allergin in Mountain Cedar Pollen"; Gross et al; Chemical Abstracts vol. 90 No. 5; p. 374; 01/29/79.
Patent Abstracts of Japan; "Modified Antigen, Its Preparation and Preventive Remedy For Allergic Disease Containing The Same", Torii Yakuhin K.K., vol. 8, No. 171 (C-271), Jan. 16, 1985.
Ando Shunsaku
Matsuhashi Tyoku
Mitsuhashi Masakazu
Usui Mitsuko
Kabushiki Kaisha Hayashibara Seitbutsu Kangaku/Kenkyujo
Schain Howard E.
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