3-Aminopyrrolidines as inhibitors of monoamine uptake

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S343000

Reexamination Certificate

active

07619096

ABSTRACT:
The present invention provides compounds of formula (I)and pharmaceutically acceptable salts thereof, which are useful for the inhibition of the uptake of one or more physiologically active monoamines (serotonin, norepinephrine, and dopamine).

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Thomas Ryckmans, et al., “First Dual NK1 Antagonists-Serotonin Reuptake Inhibitors: synthesis and SAR of a New Class of Potential Antidepressants” Bioorganic & Medicinal Chemistry Letters, 12(2), 2002, 261-264.
Sternfeld F, et al.;“Synthesis and 1-5 Serotonergic Activity of 3-A2-(Pyrrolidin-1-YL)Ethyluin Doles: Potent Agonists for the H5-HTID Receptor with High Selectivity Over the H5-HT1B Receptor” Journal of Medicinal Chemistry, 42(4), 1999, 677-690.
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