3 amino alkyl indoles for use in treating migraine

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514212, 514323, 514414, 546201, 548504, 548507, 540602, A61K 3140, C07D20914

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active

046365214

ABSTRACT:
Compounds are disclosed of general formula (I) ##STR1## wherein R.sub.1 represents an alkyl, cycloalkyl, aryl or aralkyl group;

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Espamer V., "Gramine Derivatives Antagonistic to 5-Hydroxytryptamine," Science 121: 369-370 (1955).
Freter et al., "Amidomethylierung Indolen," Liebigs Ann. Chem. 1976, pp. 241-249.
Shaw., New Agents Inhibitory to . . . Effects of Serotonin," Chem. Abst. 50:14127 (1955).
Shaw and Woolley, "Indole Carboxamidines and Aminomethylindoles . . . ," J.A.C.S. vol. 79: pp. 3561-3564 (1957).

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