3-(7'-oxo-1'-aza-4'-oxabicyclo[3.2.0]-hept-3'-YL)propionic acid

Details 3-(7'-oxo-1'-aza-4'-oxabicyclo[3.2.0]-hept-3'-YL)propionic acid 3-(7'-oxo-1'-aza-4'-oxabicyclo[3.2.0]-hept-3'-YL)propionic acid

1994-11-18

1996-12-17

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540349, 540360, 549435, 549454, 549477, 549476, 564 27, 564107, 564186, C07D498047, C07D20508, A61K 3142

Patent

active

055853730

ABSTRACT:
A derivative of 3-(7'-oxo-1'-aza-4'-oxabicyclo[3.2.0 ]hept-3'-yl)propionic acid represented by the formula ##STR1## wherein R.sub.1 is a hydrogen atom, a lower alkyl group optionally having one or more cycloalkyl groups, a lower acyl group, a benzoyl group optionally having one or more substituents or a benzyl group optionally having one or more substituents, R.sub.2 is a hydrogen atom or a carboxyl-protecting group, R.sub.3 is a hydroxyl group, an azido group, a benzenesulfonyloxy group optionally having one or more substituents, a lower alkylsulfonyloxy group optionally having one or more substituents, a tri-substituted silyloxy group or an amino group optionally having one or more substituents, provided that when R.sub.1 and R.sub.2 are hydrogen atoms, R.sub.3 is not an amino group, and a salt thereof.

REFERENCES:
King et al, Chem Abs 105, 38852 (1986).
Zhang, Chem Abs 115, 269958 (1991).
Zhang et al, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing, 100050, "Studies on the Total Synthesis of Clavaserine", Acta Chimica Sinica 51, 1125 (1993) and Translation.

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