Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1991-12-31
1993-11-02
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514349, 514563, 514616, 514619, 514622, 514567, 514885, 546297, 562455, 564155, 564157, 564158, 564169, 564170, 564171, 560 48, A61K 31165, C07C23365
Patent
active
052584070
ABSTRACT:
Certain 3,4-disubstituted phenols and pharmaceutically acceptable salts thereof are provided which mimic IL-1 activity by inducing IL-2 synthesis and subsequent IL-2 receptor expression. Specifically, the invention provides compounds of Formula I and acid addition salts thereof: ##STR1## wherein Y is ##STR2## NHSO.sub.2 or SO.sub.2 NH where R.sup.4 is H; Z is --O--, --NH--, --NR--, --S--, or other heteroatoms capable of hydrogen bonding with R.sup.4 to give a preferred conformation;
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Illig Carl B.
Latimer Lee H.
Lussier Barbara B.
Washburn William N.
Balogh Imre
Hollrah Glennon H.
Kumar Shailendra
Rosenstein Arthur
Sterling Winthrop Inc.
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