Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1993-07-09
1994-05-10
Kumar, Shailendra
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514352, 514517, 514522, 514534, 514561, 546304, 558415, 560 45, 562 46, 562433, 562435, 564163, 564168, A61K 31165, C07C23365
Patent
active
053107608
ABSTRACT:
Certain 3,4-disubstituted anilines and pharmaceutically acceptable salts thereof are provided which mimic IL-1 activity by inducing IL-2 synthesis and subsequent IL-2 receptor expression. Specifically, the invention provides compounds of Formula I and acid addition salts thereof: ##STR1## wherein Y is ##STR2## NHSO.sub.2 or SO.sub.2 NH where R.sup.4 is H; Z is --O--, --NH--, --NR--, --S--, or other heteroatoms capable of hydrogen bonding with R.sup.4 to give a preferred conformation;
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Illig Carl R.
Latimer Lee H.
Lussier Barbara B.
Washburn William N.
Weis Alexander L.
Balogh Imre
Kumar Shailendra
Rosenstein Arthur
Sterling Winthrop Inc.
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