Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1992-08-12
1994-05-10
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514549, A61K 31557
Patent
active
053107594
ABSTRACT:
In this invention methods are described by which prostaglandins of the E.sub.1 class and compounds that mimic or induce cyclic adenosine monophosphate are used to block collagenase gene expression by cells responsible for connective and support tissue breakdown. The consequence of using pharmaceutically acceptable preparations of prostaglandin E.sub.1, analogs of prostaglandin E.sub.1 or cyclic adenosine monophosphate agonists or inducers of cyclic adenosine monophosphate is to preserve and protect connective and support tissues. These methods provide new treatment modalities useful in protecting humans and animals against connective and support tissue degradation that occurs in aging, osteoporosis and osteoarthritis.
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Kulkosky Peter F.
Page Thurman K.
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