3,4-dihydroxyhydrocinnamic acid derivative

Details 3,4-dihydroxyhydrocinnamic acid derivative 3,4-dihydroxyhydrocinnamic acid derivative

2007-03-20

2007-03-20

Oh, Taylor Victor (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

C560S075000, C514S532000

Reexamination Certificate

active

11079888

ABSTRACT:
According to the invention, there is provided a novel 3,4-dihydroxyhydrocinnamic acid derivative, designated DHH105, having blood glucose lowering effects in vivo as a result of the enhancement of glucose transport mediated by the increase of insulin receptor signaling.This invention thus relates to a 3,4-dihydroxyhydrocinnamic acid derivative useful as an anti-diabetic agent, represented by the following formula I:or pharmaceutically acceptable salts thereof, to a method for preparing the compound, and to a composition for treating diabetes comprising the same as an active ingredient.

REFERENCES:
Etzenhouser et al , Mechanism of toxicity of esters of Caffeic and dihydrocaffeic acids, 2001, Bioorganic & Medicinal Chemistry, 9 (1), 199-209, (p. 1).

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