3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone der...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C544S144000

Reexamination Certificate

active

11511981

ABSTRACT:
The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

REFERENCES:
patent: 2622980 (1952-12-01), Copeland
patent: 2872372 (1959-02-01), Hull
patent: 2968557 (1961-01-01), Burgandt et al.
patent: 3140180 (1964-07-01), Fritz
patent: 3308134 (1967-03-01), Plostneiks
patent: 3551571 (1970-12-01), Pachter et al.
patent: 3564016 (1971-02-01), Schoen et al.
patent: 3715364 (1973-02-01), Hoff
patent: 3880871 (1975-04-01), Haugwitz et al.
patent: 3922163 (1975-11-01), Church et al.
patent: 4002643 (1977-01-01), Carson
patent: 4002749 (1977-01-01), Rovnyak
patent: 4053613 (1977-10-01), Rovnyak et al.
patent: 4070366 (1978-01-01), Gregorovich et al.
patent: 4259345 (1981-03-01), Cross et al.
patent: 4343923 (1982-08-01), Lenox et al.
patent: 4376110 (1983-03-01), David et al.
patent: 4436892 (1984-03-01), Zondler et al.
patent: 4489089 (1984-12-01), Wright, Jr. et al.
patent: 4493842 (1985-01-01), Furazawa et al.
patent: 4560700 (1985-12-01), Schnettler et al.
patent: 4628105 (1986-12-01), Schmid et al.
patent: 4642309 (1987-02-01), Michel et al.
patent: 4678798 (1987-07-01), Rentzea et al.
patent: 4826847 (1989-05-01), Michel et al.
patent: 4853403 (1989-08-01), Shiraishi et al.
patent: 4853404 (1989-08-01), Takamura et al.
patent: 4868304 (1989-09-01), Larock
patent: 4924000 (1990-05-01), Rentzea et al.
patent: 4966849 (1990-10-01), Vallee et al.
patent: 4971996 (1990-11-01), Shiraishi et al.
patent: 4987146 (1991-01-01), Rohde et al.
patent: 5043348 (1991-08-01), Zoller et al.
patent: 5043454 (1991-08-01), Wriede et al.
patent: 5047554 (1991-09-01), Ehrgott et al.
patent: 5051417 (1991-09-01), Nadler et al.
patent: 5057538 (1991-10-01), Shiraishi et al.
patent: 5082856 (1992-01-01), Taniguchi et al.
patent: 5089516 (1992-02-01), Shiraishi et al.
patent: 5124347 (1992-06-01), Connor et al.
patent: 5145983 (1992-09-01), West
patent: 5153217 (1992-10-01), Taniguchi et al.
patent: 5196446 (1993-03-01), Levitzki et al.
patent: 5202341 (1993-04-01), Shiraishi et al.
patent: 5206261 (1993-04-01), Kawaguchi et al.
patent: 5217999 (1993-06-01), Levitzki et al.
patent: 5258357 (1993-11-01), Muenster et al.
patent: 5278184 (1994-01-01), Artico et al.
patent: 5290947 (1994-03-01), Zoller et al.
patent: 5302606 (1994-04-01), Spada et al.
patent: 5322950 (1994-06-01), Sircar et al.
patent: 5330992 (1994-07-01), Eissenstat et al.
patent: 5332736 (1994-07-01), Carmosin et al.
patent: 5374652 (1994-12-01), Buzzetti et al.
patent: 5382593 (1995-01-01), Le Baut et al.
patent: 5389661 (1995-02-01), Sircar et al.
patent: 5397787 (1995-03-01), Buzzetti et al.
patent: 5409930 (1995-04-01), Spada et al.
patent: 5409949 (1995-04-01), Buzzetti et al.
patent: 5463052 (1995-10-01), Haga et al.
patent: RE35096 (1995-11-01), Taniguchi et al.
patent: 5565324 (1996-10-01), Still et al.
patent: 5610173 (1997-03-01), Schwartz et al.
patent: 5723665 (1998-03-01), Kato et al.
patent: 5786488 (1998-07-01), Tang et al.
patent: 5792783 (1998-08-01), Tang et al.
patent: 5834504 (1998-11-01), Tang et al.
patent: 5849710 (1998-12-01), Battistini et al.
patent: 5880141 (1999-03-01), Tang et al.
patent: 5883113 (1999-03-01), Tang et al.
patent: 5883116 (1999-03-01), Tang et al.
patent: 5886020 (1999-03-01), Tang et al.
patent: RE36256 (1999-07-01), Spada et al.
patent: 6130239 (2000-10-01), Chen et al.
patent: 6133305 (2000-10-01), Tang et al.
patent: 6248894 (2001-06-01), Phillion et al.
patent: 6310217 (2001-10-01), Lehr
patent: 6395736 (2002-05-01), Parks et al.
patent: 6451838 (2002-09-01), Moon et al.
patent: 6462072 (2002-10-01), Hamilton et al.
patent: 6653308 (2003-11-01), Guan et al.
patent: 286870 (1967-05-01), None
patent: 2012634 (1991-09-01), None
patent: 878539 (1953-06-01), None
patent: 2159360 (1973-06-01), None
patent: 2159361 (1973-06-01), None
patent: 2159362 (1973-06-01), None
patent: 2159363 (1973-06-01), None
patent: 2321656 (1973-11-01), None
patent: 3426419 (1986-01-01), None
patent: 0 252 713 (1988-01-01), None
patent: 0 304 493 (1989-03-01), None
patent: 0 351 213 (1990-01-01), None
patent: 0 525 472 (1993-02-01), None
patent: 0 566 226 (1993-10-01), None
patent: 0 580 502 (1994-01-01), None
patent: 0 626 377 (1994-11-01), None
patent: 0 632 102 (1995-01-01), None
patent: 0 662 473 (1995-07-01), None
patent: 0 769 947 (1997-05-01), None
patent: 0 788 890 (1997-08-01), None
patent: 0 810 217 (1997-12-01), None
patent: 0 934 931 (1999-08-01), None
patent: 1 082 305 (2001-03-01), None
patent: 1.398.224 (1965-05-01), None
patent: 1.599.772 (1970-08-01), None
patent: 2.689.397 (1993-10-01), None
patent: 809691 (1959-03-01), None
patent: 835473 (1960-05-01), None
patent: 62-29570 (1987-02-01), None
patent: 62-39564 (1987-02-01), None
patent: 63-141955 (1988-06-01), None
patent: 5-58894 (1993-03-01), None
patent: WO 88/07035 (1988-09-01), None
patent: WO 91/13055 (1991-09-01), None
patent: WO 91/15495 (1991-10-01), None
patent: WO 92/03736 (1992-03-01), None
patent: WO 92/07830 (1992-05-01), None
patent: WO 92/20642 (1992-11-01), None
patent: WO 92/21660 (1992-12-01), None
patent: WO 93/01182 (1993-01-01), None
patent: WO 93/23040 (1993-11-01), None
patent: WO 94/03427 (1994-02-01), None
patent: WO 94/10202 (1994-05-01), None
patent: WO 94/14808 (1994-07-01), None
patent: WO 95/01349 (1995-01-01), None
patent: WO 95/14667 (1995-06-01), None
patent: WO 95/17181 (1995-06-01), None
patent: WO 95/24190 (1995-09-01), None
patent: WO 96/00226 (1996-01-01), None
patent: WO 96/16964 (1996-06-01), None
patent: WO 96/22976 (1996-08-01), None
patent: WO 96/32380 (1996-10-01), None
patent: WO 96/40116 (1996-12-01), None
patent: WO 97/25986 (1997-07-01), None
patent: WO 97/34920 (1997-09-01), None
patent: WO 97/36867 (1997-10-01), None
patent: WO 98/07695 (1998-02-01), None
patent: WO 98/07835 (1998-02-01), None
patent: WO 98/24432 (1998-06-01), None
patent: WO 98/38984 (1998-09-01), None
patent: WO 98/45708 (1998-10-01), None
patent: WO 98/50356 (1998-11-01), None
patent: WO 98/56376 (1998-12-01), None
patent: WO 99/10325 (1999-03-01), None
patent: WO 99/19325 (1999-04-01), None
patent: WO 99/48868 (1999-09-01), None
patent: WO 99/52869 (1999-10-01), None
patent: WO 99/61422 (1999-12-01), None
patent: WO 99/65869 (1999-12-01), None
patent: WO 00/08202 (2000-02-01), None
patent: WO 00/35920 (2000-06-01), None
patent: WO 00/38519 (2000-07-01), None
patent: WO 00/56709 (2000-09-01), None
patent: WO 01/60814 (2001-08-01), None
patent: WO 01/90068 (2001-11-01), None
Abramovitch and Hey, “Internuclear cyclisation. Part VIII. Naphth[3:2:1-cd]oxindoles,”J. Chem. Soc.1697-1703 (1954), Strand, London.
Abramovitch et al., “A Novel Synthesis of a Cyclic Hydroxamic Acid Involving a Molecular Rearrangement,”Chemistry and Industry44:1871 (1967) 8Laporte Industries Limited, Lancashire.
Akbasak and Sunar-Akbasak, “Oncogenes: cause or consequence in the development of gilal tumors,”J. Neurol. Sci.111:119-133 (1992)8 Elsevier Science Publishers.
Andreani et al., “Potential Antitumor Agents. 25[1]. Synthesis and Cytotoxic Activity of 3-(2-Chloro-3-Indolymethylene)1,3-Dihydroindol-2-Ones,”Anticancer Research18:3585-3588 (1996) 8 Elsevier, Paris.
Andreani et al., “Synthesis and cardiotonic activity of 2-indolinones,”Eur. J. Med. Chem.25:187-190 (1990).
Andreani et al., “Synthesis and cardiotonic activity of 2-indolinones bearing pyridyl groups,”Eur. J. Med. Chem.28:653-657 (1993) 8 Elsevier, Paris.
Andreani et al., “Synthesis and cardiotonic activity of 2-indolinones,”Chemical Abstracts, vol. 113, abstract No. 78106 (1990).
Andreani et al., “Synthesis and cardiotonic activity of pyridylmethylene-2-indolinones,”Eur. J. Med. Chem.27:167-170 (1992) 8 Elsevier, Paris.
Andreani et al., “Synthesis and potential coanthracyclinic activity of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-

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