3,3-disubstituted piperidine derivatives and their use as therap

Details 3,3-disubstituted piperidine derivatives and their use as therap 3,3-disubstituted piperidine derivatives and their use as therap

1996-10-18

1998-09-15

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514320, 514326, 514318, 546 15, 546 16, 546 17, 546 18, 546 19, 546 20, 546193, 546194, A61K 31445, C07D22120

Patent

active

058078657

ABSTRACT:
The present invention relates to compounds of the formula (I) ##STR1## wherein X, Z, R, R.sup.1, R.sup.2, Ar, n and m are as defined herein which are of use in the treatment or prevention of neuropathy, asthma, osteoarthritis, rheumatoid arthritis or migraine.

REFERENCES:
patent: 5340822 (1994-08-01), Emonds-Alt
patent: 5350582 (1994-09-01), Emonds-alts
patent: 5434158 (1995-07-01), Shah
patent: 5559132 (1996-09-01), Miller
patent: 5589489 (1996-12-01), Shenvi
patent: 5635510 (1997-06-01), Burkholder
T. Harrison, wt al., Poster Presentation at Gordon Research Conference on Medicinal Chemistry, Colby Sawyer College, New London, New Hampshire, US (Aug. 4-9, 1996) "High Affinity, Selective Neurokinin 2 and Neurokinin 3 Receptor Antagonists from a Common Structural Template".

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