(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

Details (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid

1977-08-19

1979-12-18

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C10172

Patent

active

041795733

ABSTRACT:
This invention provides the amino acid (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid which is prepared by hydrolysis of bestatin. Bestatin is a chemical which inhibits aminopeptidase B, leucine aminopeptidase and bleomycin hydrolase, enhances the antitumor effect of bleomycin, has the chemical name [(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucine, has the following structure ##STR1## and is prepared by cultivating a strain of streptomyces which produces bestatin in a nutrient medium under aerobic conditions until substantial activity inhibitory to aminopeptidase B is imparted to said cultured medium and then recovering said bestatin from said cultured medium. A preferred strain is Streptomyces olivoreticuli FERM-P No. 2590 (A.T.C.C. 31159).

REFERENCES:
Knoop et al., [Z. Physiol Chem., vol. 239, 30-46 (1936)], Chem. Abst., vol. 30; #2583.sup.5.
Aries, Chem. Abst, vol. 83, #131311 (1975).

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