(2S,2'R,3'R)-2-(2,3-dicarboxyl-cyclopropyl)-glycine (DCG-1/4) an

Details (2S,2'R,3'R)-2-(2,3-dicarboxyl-cyclopropyl)-glycine (DCG-1/4) an (2S,2'R,3'R)-2-(2,3-dicarboxyl-cyclopropyl)-glycine (DCG-1/4) an

1999-02-23

2000-02-01

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 6104

Patent

active

060205253

ABSTRACT:
This invention relates to (2S,2'R,3'R)-2-(2,3-dicarboxyl-cyclopropyl)-glycine of formula ##STR1## wherein R.sub.2 is hydrogen or tritium and to a process for the preparation thereof. The described compounds can be used as a pharmacological tool to study the function of group II mGluR (metabotropic glutamate receptor).

REFERENCES:
Database CAPLUS on STN, Acc. No. 1995:15890, Shimamoto et al., `Synthesis of conformationally constrained glutamate analogs.` Tennen Yuki Kagobutsu Toronkai Koen Yoshishu (1993), 35th, p559-66 (abstract), 1995.
Database CAPLUS of STN, Acc. No. 1994:606018, Nakanishi et al., `Preparation of 2-(2,3-dicarboxycyclopropyl)glycine stereoisomers and G protein-coupled glutamatergic receptor agonists containing them.` JP 06024970 (abstract), 1994.
F. Sladeczek et al., Nature, 317:717-719 (1985).
F. Nicoletti et al., Journal of Neurochemistry, 46(1):40-46 (1986).
Y. Ohfune et al., Bioorganic & Medicinal Chemistry Letters, 3(1):15-18 (1993).
K. Shimamoto et al., J. Med. Chem., 39:407-423 (1996).
F. Feist, Chem. Ber., 26:747-764 (1893).
A. Blomquist et al., J. Am. Chem. Soc., 81:2012-2017 (1959).
W. Doering et al., Tetrahedron, 26:2825-2835 (1970).
J. Neff et al., J. Org. Chem., 39(26):3814-3819 (1974).
T. Gilchrist et al., Journal of the Chemical Society (C), p. 776-778 (1968).
M. Ettlinger et al., Journal of the American Chemical Society, 74(22):5805-5806 (1952).

Affiliated with

Also associated with

Rating

(2S,2'R,3'R)-2-(2,3-dicarboxyl-cyclopropyl)-glycine (DCG-1/4) an does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with (2S,2'R,3'R)-2-(2,3-dicarboxyl-cyclopropyl)-glycine (DCG-1/4) an, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and (2S,2'R,3'R)-2-(2,3-dicarboxyl-cyclopropyl)-glycine (DCG-1/4) an will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-938958