2R,4S-hydroxyitraconazole isomers

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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Details

514384, 514467, A61K 31495, A61K 3141, A61K 31335

Patent

active

061470775

ABSTRACT:
A method of treating fungal infections with a mixture of isomers of 2R,4S-hydroxyitraconazole and their sulfate and phosphate derivatives is disclosed. Pharmaceutical compositions containing these compounds are also disclosed.

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Saksena et al., "Concise Asymmetric Routes to 2,2,4-Trisubstituted Tetrahydrofurans Via Chiral Titanium Imide Enolates: Key Intermediates Toward Synthesis of Highly Active Azole Antifungals SCH 51048 and SCH 56592", Tetrahedron Letters, 37, No. 32, 5657-5660, 1996.

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