27875, 22025, 27420, 17906, 16319, 55092 and 10218 molecules...

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

Reexamination Certificate

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C435S069100, C435S069700

Reexamination Certificate

active

07098015

ABSTRACT:
The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

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Pitts, William J., et al., “Identification of Purine Inhibitors of Phosphodiesterase 7 (PDE7)”, Bioorganic & Medicinal Chemistry Letters 14:2955-2958 (2004).
Gardner, Clare et al., “Cloning and Characterization of the Human and Mouse PDE7B, a Novel cAMP-Specific Cyclic Nucleotide Phosphodiesterase”, Biochemical and Biophysical Research Communications 272:186-192 (2000).

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